- Reduces turbidity, HCP, DNA and bioburden.
- Excellent throughput and mAb recovery.
- Enhanced capture column performance and protection.
- Substantial turbidity, DNA, HCP and bioburden reduction.
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Abmessungen
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10.3 cm x 21.6 cm, 15.2 cm x 21.6 cm, 20.3 cm x 45.2 cm, 4.5 cm x 7.7 cm, 5.7 cm x 45.2 cm, 8.8 cm x 7.7 cm
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Anwendungsgebiet
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Adsorptive Tiefenfiltration, Bioburden Reduktion, Klärung der Zellkultur, Chromotographie und Säulenschutz, DNA-Entfernung, Plasmafraktionierung
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Branchen
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Biowissenschaften
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Durchflussrate (metrisch)
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0.3 Millilitre per Minute, 1 Millilitre per Minute, 100 Millilitre per Minute, 300 Millilitre per Minute, 4700 Millilitre per Minute, 50 Millilitre per Minute, 680 Millilitre per Minute, 8 Millilitre per Minute
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Filtermaterial
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vollständig synthetischer Hybrid-Aufbereiter
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Filtertyp
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Filterkapsel
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Lagertemperatur
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68
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Marke
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Emphaze™
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Maximale Betriebstemperatur (Celsius)
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40 Degree Celsius
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Produktserien
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AEX
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Rückhalterate (µm)
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0.2 μm
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Serie
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Emphaze™ AEX, Emphaze™ AEX Series
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Stück pro Packung
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1, 2, 4
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- Reduces turbidity, HCP, DNA and bioburden.
- Excellent throughput and mAb recovery.
- Enhanced capture column performance and protection.
- Substantial turbidity, DNA, HCP and bioburden reduction.
- Reduced surface area requirement of the downstream sterilizing grade membrane.
- May offer differentiated protection of the protein A column for enhanced contaminant clearance performance.
- All product components comply with United States Pharmacopeia (USP) Class VI 70°C Biological Reactivity Tests, in vivo.
3M™ Emphaze AEX Hybrid Purifier is our single-use sterilisable and sanitisable. The all-synthetic purification media that contains a Q-functional anion exchange media and a fine particle and bioburden reduction membrane.
Remove impurities in biopharmaceutical process streams such as DNA, host cell proteins (HCP) and viruses with our all-synthetic, single use 3M™ Emphaze AEX Hybrid Purifier.
The composite purification media is comprised of three primary components: anion exchange nonwoven, microporous membrane, and membrane support. The anion exchange media is composed of four layers of polypropylene nonwoven with a covalently attached quaternary ammonium functional polymer.
The bioburden reduction membrane is a highly asymmetric polyamide membrane which has nine zones of decreasing pore size, spanning approximately a 20 X range, and terminating with a 0.2 μm rated qualifying layer. This is followed by a polypropylene nonwoven used as a support layer in the capsule.
Capsules
There are two primary capsule configurations for the Emphaze AEX Hybrid Purifier, Laboratory and Scale-up capsules:
- The Laboratory capsule (BV8) has an 8ml bed volume.
- The Scale-up capsules are constructed from a lenticular media cell design having bed volumes of 120 mls and 360 mls (BV 120 and BV 360 respectively).
- The Production capsules are scaled to meet your manufacturing requirements and utilise manifolds in a holder for ease of use.
A full support package is available for 3M Emphaze AEX Hybrid Purifiers. This package includes Installation and Operation Guides, a Certificate of Quality and a Regulatory Support File.
Empfohlene Anwendungen
- Geeignet für die Klärung von Säugetierzellkulturen und die Optimierung von Downstream-Prozessen für monoklonale Antikörper (mAbs)
- Einsatz bei der Herstellung von virus-basierten Impfstoffen
- Optimierte Klärung in Downstream-Prozessen für rekombinante Proteine
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